Covid-19 Ivermectin

Molnupiravir is the most advanced of the novel antiviral drugs undergoing clinical development and trials, whilst Ivermectin is the most studied “repurposed” medication globally, in randomized clinical trials, retrospective studies and meta-analyses.

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Molnupiravir (EIDD2801/MK-4482) is a pro-drug of the novel active antiviral nucleoside analogue β-d-N4-hydroxycytidine (NHC,
EIDD1931) [1]. It’s a broad spectrum antiviral agent against SARS-CoV-2, SARS-CoV,seasonal or pandemic influenza and MERS corona virus [1]. The basic and clinical pharmacological properties are shown on Table 1.
Ivermectin is an FDA-approved, WHO essential drug used as broad spectrum antiparasitic, antibiotic and which has demonstrated broad spectrum antiviral activity against RNA viruses, including HIV, Zika, MERS corona virus. It is being repurposed as a therapeutic agent for COVID-19

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Pharmacodynamics
Antiviral mechanisms

• Cell viral entry-hACE2 receptor. Binds to active sites of spike protein S. Inhibits human cell entrance of virus via h-ACE2
• Nuclear transport -importin α/β1 Binds Importin α to prevent link with β1 and nuclear transport of viral and host proteins.
• RNA dependent, RNA polymerase (RdRp) Binds to and inhibits viral RdRp replication and transcription complex with -9.7Kcal/mol energy

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Uporabnik mosseero je napisal:

Imaš se za antivaxx specialista, potem pa takole oslarijo streseš. Sinovac je klasično cepivo, ni vektorsko. Za povrh je to kitajec (že ime Sino- ti to pove) in nima nobene zveze z Indijo.

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